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Co-writer and actor in Hungry Mile Theatre company's production of Citizen Gef.
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Stiffness-dependent enhancement of inflammation was associated with increased expression of Rho activator, GEF-H1.
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We show here that the Rho family GEF Vav2 plays a key role in this process.
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The possible use of dominant negative ras-specific GEFs as a tool to down-regulate tumor growth is discussed.
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These studies demonstrate that siRNAs are an ideal research tool for the assignment of Rho GEF function in vivo.
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In this Review, we assess the association of GEFs and GAPs with cancer and their druggability for cancer therapeutics.
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There was all party support for a motion to allow Ireland to join the Global Environmental Facility (GEF).
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GEF is a funding mechanism for the UN convention on biological diversity and the UN framework convention on climate change.
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Rho GTPase activity is temporally and spatially regulated by a set of specific guanine nucleotide exchange factors (GEFs).
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Calculated GEF for the tested PAHs were similar in all cell lines and generally higher than the TEF usually used.
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Arf activation is spatially and temporally regulated by distinct guanine nucleotide exchange factors (GEFs) at different Golgi compartments.
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Inhibition of ECM crosslinking and stiffening by LOX suppression reduced EC inflammatory activation and GEF-H1 expression in response to LPS.
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GEF activity was reduced from control values in extracts of heat-shocked cells and serum-deprived cells, concomitant with increased eIF-2 alpha phosphorylation.
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The phenotype differs from that previously reported in families presenting FS or generalized epilepsy with febrile seizures plus (GEFS+).
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These findings present a novel mechanism of stiffness-dependent exacerbation of vascular inflammation and escalation of ALI via stimulation of GEF-H1-Rho pathway.
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Here we found that RINL has GEF activity for the Rab5 subfamily proteins by measuring their GTP-bound forms in cultured cells.